A mysterious virus hits an isolated elementary school, transforming the kids into a feral swarm of mass savages. An unlikely hero must lead a motley band of teachers in the fight of their lives.

After being kicked out of his rock band, guitarist slacker Dewey Finn faces a mountain of debts and depression. He shares an apartment with his best friend, Ned Schneebly, an old band member who is now a substitute teacher. Dewey accepts a job as a substitute teacher at a snobbish private elementary school where his attitude and hijinks have a powerful result on his students. He learns they are talented young musicians, and he decides to form a rock band with them to win the $10,000 prize money...

6th Grade gets a new substitute teacher. She wants to train the class for an international competition in Paris. But something isn't right. How is she able read kids' minds? Why is she so mean? And how does she manage to convince everyone's parents she is so great when the whole class knows she is really an alien?